Advances in molecular mechanisms of browning of white adipose tissue
10.16571/j.cnki.1008-8199.2015.07.022
- VernacularTitle:白色脂肪组织棕色化调控机制的研究进展
- Author:
Ming NI
;
Jinyan WANG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Brown adipose tissue;
White adipose tissue;
PPARγ;
PRDM16;
PGC-1α
- From:
Journal of Medical Postgraduates
2015;(7):771-775
- CountryChina
- Language:Chinese
-
Abstract:
Brown and white adipocytes have different metabolism characteristics.White adipocytes promote the formation and development of atherosclerosis.However, brown adipocytes contribute to the control of atherosclerosis.Brown and white adipocyte phe-notypes can transform mutually.This article will elaborate the pathogenesis of the transformation between brown/white adipocyte pheno-types regulated by transcription factors(such as PPARγ, PRDM16, PGC-1α), co-regulators, hormones, proteins, signal molecules, oxidative stress and miRNAs.
