Animal model of arterial vulnerable plaque for imaging study using balloon-injury method

VernacularTitle:基于成像技术采用内膜损伤法构建动脉易损斑块动物模型方法研究
Author: Xiaoyi DUAN ; Jia FANG ; Lei DENG ; Jin SHANG ; Jing SHANG ; Faliang SONG
Publication Type:Journal Article
Keywords: vulnerable plaque; ultrasound; magnetic resonance imaging; animal model
From: Journal of Practical Radiology 2015;(5):840-843
CountryChina
Language:Chinese
Abstract: Objective To establish animal model of arterial vulnerable plaques for molecular imaging study.Methods Fifteen New Zealand white rabbits were randomly divided into high lipid diet+balloon-injury group (A),high lipid diet group (B)and regular diet group (C).Ultrasound (US)and magnetic resonance (MR)imaging were used to dynamically observe the formation of plaque in abdominal aorta. Results were compared with blood lipid level and pathological indicators.Results At 4 weeks,several plaques could be seen in group A.The plaque number increased rapidly and reached to 22 at 12 weeks,which was in parallel with the change of blood lipid. Only a few plaques were observed in group B,while no vulnerable plaque was revealed in group C.All the plaques were judged to be soft plaques on US and MR images,which was consistent with the macrophages gathering and smooth muscle cell proliferating in plaques.Conclusion High lipid diet+balloon-injury is an ideal method to build animal model for molecular imaging of atherosclerotic plaque.