Role of parecoxib in protection of learning and memory ability in rats with transient global cerebral ischemia/reperfusion inj ury

VernacularTitle:帕瑞昔布对大鼠全脑缺血再灌注损伤中学习和记忆能力的保护作用
Author: Pengchong XIAO ; Li MEI ; Zhaojun WANG ; Guangyan ZHANG ; Jianxiu CUI
Publication Type:Journal Article
Keywords: Paricoxib; Global cerebral ischemia/reperfusion; Learning and memory; Morris water maze
From: The Journal of Practical Medicine 2014;(24):3922-3925
CountryChina
Language:Chinese
Abstract: Objective To explore the role of parecoxib in protection of learning and memory ablility in rats with global cerebral ischemia/reperfusion injury. Methods Male Wistar rats were randomly divided into a sham group (S group), a ischemia/reperfusion group (I/R group), and a ischemia/reperfusion with parecoxib group (I/R+PA group). Global cerebral ischemia was induced by Pulsinelli 4-vessel occlusion. 72 h after reperfusion, Morris water maze was used to assess spatial learning and memory ability for consecutive five days. The histological changes in the hippocampus were detected by Nissl staining. Results As compared with the I/R group, rats in S guoup and I/R+PA group had a significantly shortened escape latency (P<0.05), and had significantly longer dwelling time in the former platform quadrant and more frequent cross-platform movement in the Morris water maze test. Conclusions Parecoxib plays a role in protection of learning and memory ability in rats with global cerebral ischemia/reperfusion injury.