The relationship between the serum SRC-3 levels and the bone loss severity in the postmenopausal women
10.3969/j.issn.1006-5725.2014.24.018
- VernacularTitle:绝经后妇女血清SRC-3表达水平与骨量丢失程度的相关性分析
- Author:
Weimin DENG
;
Qiushi WEI
;
Xin TAN
;
Simin HUANG
;
Junling WANG
;
Yu SHAO
;
Hairong SU
- Publication Type:Journal Article
- Keywords:
Postmenopausal osteoporosis;
SRC-3;
bone loss
- From:
The Journal of Practical Medicine
2014;(24):3932-3934
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the serum SRC-3 levels and the bone loss severity in postmenopausal women. Methods Fifty-eight PMW with osteopenia or osteoporosis and nineteen healthy PMW were enrolled in this study from June 2012 to September 2013. BMD at the lumbar spine and femoral neck were observed by DXA Lunar Prodigy Vision. The levels of serum SRC-3 were detected by ELISA. The diagnosis value was evaluated by the ROC curves analysis. Results The levels of serum SRC-3 were significant higher in the normal group than those in the osteopenia or the osteoporosis groups (P<0.001 for both), no statistical significance was found between the osteopenia and the osteoporosis group(P=0.056). The levels of serum SRC-3 were negatively correlated with the BMD diagnosis grading (r=-0.543, P < 0.001). By using the ROC curve analysis, the serum level of SRC-3 for PMW with osteoporosis and osteopenia were found to be 0.297 ng/mL and 0.347 ng/mL, respectively. The levels of serum SRC-3 were positively associated with BMI (r=0.395, P<0.001) and LS-BMD (r=0.503,P<0.001) in the postmenopausal women. Conclusion SRC-3 might be an useful index to reflect the severity of lumbar spine bone loss.
