Correlation between 1-hour postload plasma glucose levels during an oral glucose tolerance test and fasting serum lipid profiles in normoglycemic individuals with overweight in Hefei suburban areas ZHANG Yun*, CHEN Ming-wei, ZHAO Li-li, WANG Qiong, WU Fei-fei, XIA Tong-jia, YU Ben-fu, WANG You-min. Correlation between 1-hour postload plasma glucose levels during an oral glucose tolerance test and fasting serum lipid profiles in normoglycemic individuals with overweight in Hefei suburban areas
10.3969/j.issn.1006-5725.2014.23.019
- VernacularTitle:合肥市郊区糖耐量正常的超重人群中口服糖耐量试验1小时血糖与空腹血脂的相关性
- Author:
Yun ZHANG
;
Mingwei CHEN
;
Lili ZHAO
;
Qiong WANG
;
Feifei WU
;
Tongjia XIA
;
Benfu YU
;
Youmin WANG
- Publication Type:Journal Article
- Keywords:
Oral glucose tolerance test;
One-hour plasma glucose level;
Triglyceride;
High-density lipoprotein-cholesterol;
Overweight
- From:
The Journal of Practical Medicine
2014;(23):3765-3768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the association between one-hour plasma glucose (1-hPG) level during an oral glucose tolerance test (OGTT) and serum lipid profiles in individuals with NGT. Methods 6 402 individuals with NGT who underwent a 75 g OGTT were screened from four communities of Hefei suburban areas, aged over 40 years. Then 1 291 cases of NGT were randomly selected as the object of this research by random data table method. They were divided into NGT-1 group (1-h PG < 8.6 mmol/L, n = 597)and NGT-2 group(1-h PG≥8.6 mmol/L, n = 694). Pearson correlation analysis and multivariate linear regression analyses were performed to assess correlations between 1-h PG levels and lipid profiles. Results (1) The average values of body mass index were 24.3 kg/m2 in NGT-1 group, and 24.5 kg/m2 in NGT-2 group. (2) Compared with individuals in NGT-1 group , fasting plasma glucose , two-hour plasma glucose during OGTT , HbA1c , triglyceride (TG), and high-density lipoprotein-cholesterol(HDL-c) levels, TG/HDL-c ratios, and total cholesterol(TCH)/HDL-c ratios were significantly higher in individuals than in NGT-2 group. By contranst, body mass index, blood pressure , TCH and low-density lipoprotein-cholesterol levels were not significantly different between NGT-1 group and NGT-2 group. (3) The multiple linear regression analyses showed that 1 h PG levels positively correlated with TG in individuals in both NGT-1 group and NGT-2 group (P < 0.01). In addition, 1-h PG levels negatively correlated with HDL-c ratio in both groups (P < 0.01). Conclusion 1-h PG levels during OGTT in overweight individuals with NGT closely correlate with HDL-c and TG levels.
