Investigation on the distribution of weak D and Del phenotype in unrelated blood donors with negative Rh(D)
10.3969/j.issn.1006-5725.2014.24.055
- VernacularTitle:初筛Rh（D）阴性无缘献血者弱D和Del表型调查
- Author:
Song ZHANG
;
Li CHANG
;
Renhao SONG
- Publication Type:Journal Article
- Keywords:
Preliminary screening;
RhD (-) blood group;
Weak D phenotype;
Del phenotype
- From:
The Journal of Practical Medicine
2014;(24):4028-4030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of weak D and Del phenotype in unrelated blood donors with negative Rh (D). Methods Four hundred and nineRhD (-) unrelated donors were screened by the saline agglutination method. Type weak D was detected by the indirect antiglobulin test, and type Del was detected by absorb radiation method. Results In 409 RhD (-) samples, 27 cases (6.61%) of type weak D were checked out, and 61 cases (14.91%) were type Del and 321 cases (78.48%) were corroborate for RhD (-), In the confirmed RhD (-) blood donors, phenotype ccee was most (49.14%), followed by Ccee (23.47%), People with phenotype ccEe accounted for 4.16%in type weak D, followed by Ccee (1.71%). Ccee accounted for 10.02%in type Del, and Ccee accounted for 1.71%. Conclusion RhD (-) donors screened by regular testing should adopt a more sensitive test for verifing type weak D or Del. In order to ensure the security of blood transfusion, people with type weak D and Del should be regarded as RhD positive blood donors, and the RhD negative people deemed to be recipients.
