Effects of Qingfeitang on ET-1 and PGE2 in exhaled breath condensate and serum of patients with ARDS
10.3969/j.issn.1006-5725.2014.23.051
- VernacularTitle:清肺汤对急性呼吸窘迫综合征患者呼出气冷凝液和血清中内皮素－1、前列腺素E2的影响
- Author:
Yan GU
;
Jianrong CHEN
;
Feng SHAO
;
Xiang GAO
;
Yanfen TANG
;
Zhihua XU
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome;
adult;
Qingfeitang;
Exhaled breath condensate;
Endothelin-1;
Prostaglandin E2
- From:
The Journal of Practical Medicine
2014;(23):3853-3855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of endothelin-1 (ET-1) and prostaglandin E2 (PGE2) in exhaled breath condensate (EBC) and serum of patients with acute respiratory distress syndrome (ARDS) after treated by Qingfeitang and investigate its clinical value. Methods 52 ARDS patients receiving mechanical ventilation at intensive care unit (ICU) were divided into the Qingfeitang treatment group and the control group, with 26 cases in each group. The EBC were collected by Ecoscreen condenser within 24 h after diagnosis of ARDS and on the 5th day of medication, and the venous blood were collected at the same time. The levels of ET-1 and PGE2 in the EBC and serum of different period were measured by EIA. Results (1) After treatment, The levels of ET-1 in EBC and serum of the Qingfeitang treatment group were significantly lower than those of the control group. (2) After treatment, the levels of PGE2 in serum of the Qingfeitang treatment group were significantly lower than that of the control group. (3) The oxygenation index difference before and after treatment of Qingfeitang in the treatment group was higher than in the control group. (4) The duration of mechanical ventilation of the Qingfeitang treatment group was significantly less than that of the control group. Conclusions Qingfeitang could be an effective method for alleviating acute respiratory distress syndrome.
