Chronopharmacological study of different antidepressants in mice
10.3936/j.issn.1002-0152.2014.12.001
- VernacularTitle:不同抗抑郁药在小鼠体内的时辰药理学研究
- Author:
Zaoqin YU
;
Chengliang ZHANG
;
Daochun XIANG
;
Yanjiao XU
;
Xiping LI
;
Li LUO
;
Jingjin JIN
;
Dong LIU
- Publication Type:Journal Article
- Keywords:
Antidepressants;
Chronopharmacology;
Forced Mice Swimming Test;
Circadian Rhythm
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(12):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of different administration time on antidepressant effect of seven clinical common antidepressants. Methods Male mice were randomly divided into eight groups:venlafaxine (75 mg/kg), sertraline (20 mg/kg), fluoxetine (20 mg/kg), doxepin (15 mg/kg), mirtazapine (15 mg/kg), citalopram (40 mg/kg), trazodo?ne (50 mg/kg) and control (saline) groups. Each group contained 36 mice. Drugs were administered to 6 mice per group 30 min before forced swimming test at the 6 time points (9:00, 13:00 and 17:00 as light phase and 21:00, 1:00 and 5:00 as dark phase). Forced swimming test was applied to determine the influence of dosing time on anti-immobility effect of seven antidepressants at each time point. Results Immobility time in venlafaxine group and sertraline group significant?ly decreased compared with that of control group at all time points(all P<0.05). Moreover, anti-immobility effects of ven?lafaxine, fluoxetine, mirtazapine and doxepin were better during the dark phase than during the light phase (all P<0.05). In addition, immobility time in sertraline group decreased at the late part of dark phase (5:00) and the early part of light phase (9:00) compared with other phases (P<0.05). Conclusions Most antidepressants show 24-h rhythm dependent an?ti-immobility effects, but rhythmic patterns are not completely consistent among different antidepressants. Further study is needed to explore the chronopharmacological mechanism and clinical applications of these antidepressants.
