Effect of restraint stress at different periods on SOD and MDA of normal rat serums and mucosal tissues

VernacularTitle:不同时间束缚应激对大鼠血清和胃黏膜组织中SOD、MDA的影响
Author: Hongyan ZHOU ; Wenbin QIE ; Junlin WEN ; Weifeng TU
Publication Type:Journal Article
Keywords: Restraint stress; AGML; SOD; MDA
From: The Journal of Practical Medicine 2014;(24):3912-3915
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of restraint stress (RS) in different periods on SOD and MDA of normal rat serums and mucosal tissues. Methods 32 adult male Wistar rats were randomly divided into normal control group (NC group, n=8), and restraint stress groups of 3 days, 5 days and 7 days (RS3, RS5 and RS7 groups, n=8 at each group). The comparisons were done between all the groups in terms of the general extent of gastric mucosal injury, gastric mucosal injury ulcer index (UI), water content, the activity of super oxide dismutase (SOD), and the level of malondialdehyde (MDA) in serum and mucosal. Results Compared with NC group, gastric mucosal injuries in RS group were more severe, the UI and water content was proportionally related with the restraint periods. Meanwhile, the serum and mucosal SOD in the RS groups were all increased, and with prolonged restraints, the SOD were decreased, but the serum and mucosal MDA were increased (P<0.01) and SOD/MDA in the mucosa lowered as well (P<0.01). Conclusion Restraint stress may cause mucosal injury proportional to the stress time and related with lowered SOD/MDA in mucosal tissues.