Correlation Analysis on Chemical and Physical Quality Attributes of Tanshinone Extract Powders
10.11842/wst.2014.12.010
- VernacularTitle:丹参酮提取物物理化学质量属性相关性分析＊
- Author:
Gan LUO
;
Bing XU
;
Fei SUN
;
Xianglong CUI
;
Xinyuan SHI
;
Yanjiang QIAO
- Publication Type:Journal Article
- Keywords:
Tanshinone extract powders;
cryptotanshinone;
tanshinone IIA;
physical and chemical quality attributes;
canonical correlation analysis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(12):2575-2581
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to find out the correlation between chemical component contents and physical prop-erties of tanshinone extract powders. The contents of cryptotanshinone and tanshinone IIA from 50 batches of tanshi-none extract powders were determined by HPLC. And the physical properties were determined by classical methods. The correlation analysis between component contents and physical properties were also investigated. The results showed that two sets of variables had good intraclass correlation, especially for the contents of cryptotanshinone and tanshinone IIA, among D10, D50, D90, there were relatively strong correlation between the bulk density and tapped density, between the Hausner ratio and compressibility index. The angle of repose had a certain correlation with the uniformity, Hausner ratio and compressibility index, but with no strong correlation. The correlation coefficient be-tween two sets was below 0.400, suggesting there was a not so good inter-group correlation. After the canonical cor-relation analysis, three pairs of canonical variables had significant correlations with correlation coefficients being 0.851, 0.674 and 0.565, respectively. It was concluded that there was a good intraclass correlation for each of physi-cal and/or chemical quality set, but the correlation between the two sets was bad. Canonical variables performed bet-ter inter-group correlation compared with original variables, indicating there was a certain correlation between chem-ical and physical quality attributes of tanshinone extract powders.
