Expression of Periostin in Craniopharyngioma Involving Third Ventricular Floor and its Relationship to Hypothalamus Functions

VernacularTitle:三脑室底型颅咽管瘤骨膜蛋白表达及其与下丘脑功能的关系
Author: Ming CHEN ; Yi LIU ; Yongfu CAO ; Jun PAN ; Jin SHI ; Chaohu WANG ; Renkuan WAN ; Zhanpeng FENG ; Chunmei YIN ; Songtao QI
Publication Type:Journal Article
Keywords: Craniopharyngioma; Periostin; Hypothalamus; Prognosis
From: Chinese Journal of Nervous and Mental Diseases 2014;(11):677-681
CountryChina
Language:Chinese
Abstract: Objective To evaluate the expression and clinical significance of Periostin (POSTN) in craniopharyngi?oma. Methods Forty-two patients with pathologically diagnosed adamantinomatous craniopharyngioma involving the floor of 3rd ventricle were retrospectively analyzed. The correlation between expression of POSTN and outcome was studied. Results POSTN was expressed in stroma of craniopharyngioma tissues. The expression of POSTN was not associated with the postoperative recurrence (Z=-0.236,P=0.813) while was associated with the degree of the adhesion between tumor and floor of 3rd ventricle (r=0.685, P<0.001), postoperative Hypothalamic Status Scale (r=0.569, P<0.001) and Body Mass Index (r=0.594, P<0.001). Conclusions POSTN may predict the degree of the adhesion between craniopharyngioma and 3rd ventricle floor. The high expression of POSTN may indicate the worse hypothalamus function.