Influence on expressions of inflammatory cytokines by different postoperative analgesic in elder patients with hip replacement
10.3969/j.issn.1006-5725.2014.23.016
- VernacularTitle:两种术后镇痛方式对老年髋关节置换术患者炎性因子表达的影响
- Author:
Yi LU
;
Weifeng TU
;
Xinhua YAO
;
Jianhua LU
- Publication Type:Journal Article
- Keywords:
Patient-controlled analgesia;
Hip replacement;
Inflammatory cytokines
- From:
The Journal of Practical Medicine
2014;(23):3755-3758
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate influence of patient-controlled intravenous analgesia (PCIA) and patient-controlled epidural analgesia (PCEA) on expressions of serum inflammatory cytokines in elderly patients with hemi or whole hip replacement using cemented artificial joint. Methods Elderly patients undergoing hip replacement were selected and were divided into PCIA group and PCEA group. VAS scores were calculated at 12 h postoperatively. Patients whose VAS scores were not more than 2 at postoperative 12h were included. 30 cases in each group were finally included. Fifteen cases were randomly chosen in each group and underwent sample blood drawing for assays. Expressions of serum inflammatory cytokines were detected by ELISA , RT-PCR and Western-blot. Results Gene and protein expressions of TNF-a as well as IL-6 in group PCEA were lower and expression of IL-10 was higher than that in group PCIA. Serum level of TGb-β was higher in group PCEA detected by ELISA. There was no significant difference in expression of IL-8 between groups. Conclusions PCEA may better promote expressions of anti-inflammatory cytokines and inhibit expressions of proinflammatory cytokines. PCEA is superior in maintenance of inflammatory cytokine balance.
