Relationship between hotspot mutations in basic core promoter of hepatitis B virus and familial clustering of hepatocellular carcinoma in Guangxi
10.3969/j.issn.1006-5725.2014.23.018
- VernacularTitle:乙型肝炎病毒基本核心启动子区热点突变与广西肝癌家族聚集性的相关性
- Author:
Renfang SHI
;
Jizhou WU
;
Peiqi WAN
;
Jianlin WU
;
Qiuyue NING
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Basic core promoter;
Mutation;
Hepatocellular carcinoma;
Familial clustering
- From:
The Journal of Practical Medicine
2014;(23):3762-3765
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between mutations in basic core promoter (BCP) of hepatitis B virus (HBV) and familial clustering of hepatocellular carcinoma (HCC) in Guangxi. Methods 153 pairs of members with HBsAg-positive were selected and matched from HCC high-incidence families and carcinoma-free families in Guangxi. The BCP genes were amplified and sequenced. Results The hotspot sites of the previous five mutations in BCP were T1762, A1764, G1775, V1753, G1803. In univariant analysis, HBV DNA≥105 copies/mL, T1762, A1764 and V1753 mutations were associated with the HCC high-incidence (P <0.05). The multivariate logistic analysis showed that HBV DNA≥105 copies/mL and A1764 were independent risk factors for it. Conclusion HBV DNA level, the mutations in BCP showed correlations with familial clustering of HCC in Guangxi.
