Association between plasma homocysteine and cystathionine β synthase gene T833C polymorphism in Xinjiang Kazakh population with essential hypertension
10.3969/j.issn.1006-5725.2014.23.022
- VernacularTitle:同型半胱氨酸及胱硫醚β合成酶T833C多态性与新疆哈萨克族原发性高血压的相关性
- Author:
Lei ZHANG
;
Weijuan CAI
;
Licui ZHANG
;
Hongmei ZHANG
;
Jiang CHENG
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Homocysteine;
Cystathionineβsynthase;
Gene polymorphism;
Kazakhs
- From:
The Journal of Practical Medicine
2014;(23):3775-3778
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the plasm homocysteine (Hcy) levels and cystathionine β synthase (CBS) T833C gene polymorphism in Xinjiang Kazakh with essential hypertension. Methods 239 Kazak patients with hypertension (hypertension group) and 206 with normotensive (control group) were selected for the study. Amplification Refractory Mutation System (ARMS) was used to analyze the polymorphism of CBS gene T833C, TT, TC and CC genotypes and the various sites of T, C allele frequencies in research group and the control group. Results Plasma of Hcy level was higher in the hypertensive group than those of control group, the difference was significant (P<0.05), and the individual plasma of Hcy with TC gene was higher than that with TT gene. The C allele frequencies was significantly higher in EH group than that in controls in Xinjiang Kazakh population, and the difference was significant (P<0.05). The risk of EH group in individuals carrying TC genetype was 2.39 times higher than in individuals carrying TT genetype (OR = 2.39, 95%CI:1.125 ~5.076, P = 0.02). Conclusion Elevated Hcy level may be a risk factor of Kazakhs hypertension in Xinjiang. The Cystathionine β synthase gene of T833C polymorphism may be associated with essential hypertension in Kazak people in Xinjiang.
