The analysis on correlation between childhood physical abuse and monoamine oxidase A polymorphisms in domestic violence
10.3936/j.issn.1002-0152.2014.10.002
- VernacularTitle:单胺氧化酶A基因rs1137070多态性与儿童期躯体受虐在新疆酒精依赖患者家庭暴力发生中的交互作用
- Author:
Shaohong ZOU
;
Zongfeng ZHAO
;
Xiangdong XU
;
Hongbing DONG
;
Gaiyu TONG
- Publication Type:Journal Article
- Keywords:
Violent behavior;
Monoamine oxidase A;
childhood physical abuse;
Interaction effects
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(10):580-584
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the interaction between environmental factors and monoamine oxidase A (MAOA) gene polymorphism in Han and Uygur on alcoholics in Xinjiang. Methods The data of childhood abuse and domestic aggressive behaviors were collected from 284 patients with alcohol dependence from Xinjiang using self-made questionnaires, Modified Overt Aggression Scale (MOAS) and Barratt Impulsivity Scale-11 (BIS-11). The meth?ods of PCR and DNA sequencing technique were conducted to detect rs1137070 single nucleotide polymorphism loci of MAOA gene. Logistic regression analysis was performed to adjust for interaction effects of gene and childhood abuse on domestic violence. Results The scale evaluation identified 143 patients with and 138 patients without domestic violence. Childhood abuse and gene were both risk factors in domestic violence. The interaction effect of childhood abuse with rs1137070 was significant. the relative excess risk, the interaction attribution ratio and the interaction index were 1.00,0.14 and 1.20, respectively. Conclusions The interactions between genes and environmental risk factors may contribute to the domestic violence in Han and Uygur on alcoholics in Xinjiang.
