The association between the Uygur patients with schizophrenia and CMYA5 polymorphism
10.3936/j.issn.1002-0152.2014.12.005
- VernacularTitle:CMYA5基因多态性与新疆维吾尔族精神分裂症的关联性研究
- Author:
Xiao LUO
;
Lili ZHANG
;
Shuxian HAN
;
Zhiguo AN
;
Qizhong YI
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cardiomyopathy Associated 5 (CMYA5);
rs3828611;
Single Nucleotide Polymor-phism
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(12):726-730
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between Cardiomyopathy associated 5 (CMYA5) polymor?phisms and schizophrenia in the Uygur Chinese population. Methods Taq-man assay was used to detect CMYA5 gene rs3828611 in 684 schizophrenia patients and 678 healthy controls from Chinese population. The positive and negative symptoms scale (PANSS) was used to evaluate patients’symptoms. Results Neither the genotype nor the allele frequen?cies of rs3828611 was significantly different between the patients and the controls (P>0.05). The differences were not sig?nificant in either each gender subgroup or in each age (teenager and adult) subgroup (P>0.05). The total score and the sub scores of PANSS were not significantly different among patients with different genotype groups (P>0.05). Conclu?sions There is no association between CMYA5 rs3828611and schizophrenia in the Uygur Chinese population.
