The study of the association between COMT polymorphisms and methylphenidate response in the treat-ment of attention deficit hyperactivity disorder
10.3936/j.issn.1002-0152.2014.12.006
- VernacularTitle:注意缺陷多动障碍COMT基因多态性与哌甲酯疗效研究
- Author:
Min CHEN
;
Haimei LI
;
Yufeng WANG
;
Li YANG
- Publication Type:Journal Article
- Keywords:
Attention Deficit Hyperactivity;
Disorder;
Catechol-o-methyltransferase Methylphenidate;
Genetic Association Study
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(12):731-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impacts of catechol-O-Methyltransferase (COMT) gene polymorphisms on the outcomes of methylphenidate treatment for attention deficit hyperactivity disorder (ADHD) in children. Methods One hundred seventy-seven ADHD children of Chinese Han descent received open-labelled dose titration with methylpheni?date to achieve optimal response in 2~4 weeks. The behavior changes were evaluated by using ADHD diagnostic scale (parent version) before and after treatment. COMT gene rs4680 (Val158Met) and rs165599 were genotyped using fluores?cent real-time PCR. The genotype distribution and treatment outcomes including remission, response and non-response were analyzed. Results The treatment response differed significantly among patients with different genotypes of rs4680 (P<0.01). Thirty-eight (40.9%) patients with G/G genotype had remission and 19 (20.4%) had good response;Thirty-five (48.6%) patients with G/A genotype had remission and 16 (22.2%) had good response. In contrast, only one patients with A/A genotype had remission and none of them had good response. The changes of the ADHD diagnostic scale total scores, inattention scores and hyperactivity impulsive scores were statistically different among different genotypes of rs4680 (P<0.05). The hyperactivity impulsive scores were significantly higher in the G allele carrier than A allele carrier (P=0.04). The treatment response was not significantly different among different rs165599 genotypes (P>0.05). Conclu?sion COMT gene rs4680 (Val158Met) polymorphism is associated with methylphenidate response in a Han Chinese popu?lation. Patients with G allele is more likely to benefit from methylphenidate treatment in comparison with A/A genotype.
