Localization of genetic susceptibility loci for bipolar disorder on chromosome 20 in Shandong peninsular

VernacularTitle:山东半岛地区双相情感障碍20号染色体基因扫描研究
Author: Meng LUAN ; Shanshan SHI ; Xing CHEN ; Peng ZHOU ; Xuerun CHANG ; Yuanxun WANG ; Gang CHEN
Publication Type:Journal Article
Keywords: Bipolar disorder; Chromosome; Genome; Association
From: Chinese Journal of Nervous and Mental Diseases 2014;(12):736-740
CountryChina
Language:Chinese
Abstract: Objective To identify the genetic loci associated with bipolar disorder in Chinese population by the ge?nome scan on chromosome 20 in bipolar disorder patients and healthy people from Shandong peninsula. Method Geno?typing was conducted on DNA pool samples of 104 bipolar disorder patients and 1000 controls using thirteen microsatel?lite markers on chromosome 20 spaced at intervals of approximately 10 cM and GeneMapper 4.0 software. CLUMP soft?ware was used to analyze multiallelic markers. Result Significant difference of allele frequencies was found at marker D20S186 (20p12.2) between patients and controls (P=0.022). Conclusion The data suggest that the D20S186 locus (20p12.2) is significantly associated with susceptibility to bipolar disorder in a Chinese Han population in Shandong pen?insula. Future studies should focus on the fine mapping of this region and assessment of candidate genes.