Research on the progress of EGFR inhibitors in tumor inhibition and radio-sensitization
10.3969/j.issn.1000-8179.20150390
- VernacularTitle:EGFR抑制剂对肿瘤的抑制和放疗增敏作用研究进展
- Author:
Yang CHEN
- Publication Type:Journal Article
- Keywords:
radiotherapy;
EGFR;
radio-sensitivity;
EGFR inhibitors
- From:
Chinese Journal of Clinical Oncology
2015;42(11):580-584
- CountryChina
- Language:Chinese
-
Abstract:
Radiotherapy is important in cancer treatment, but improving the therapeutic effect of irradiation and decreasing its toxicity to normal human tissues is still a global problem. Epidermal growth factor receptor (EGFR) is a member of ErbB family and is an important transmembrane receptor with signal-transduction tyrosine kinase activity. EGFR can direct cellular migration, adhesion, proliferation, differentiation, and apoptosis, and plays a fundamental role in the development and growth of many types of human tumor cells. A series of preclinical studies showed that EGFR inhibitors can enhance the antitumor activity of ionizing radiation. EGFR inhibi-tors regulate radio-sensitization through multiple mechanisms, including cell cycle alterations, DNA repair modulation, and anti-angio-genesis. Reasonable application of EGFR inhibitors will effectively increase the radio-therapeutic effect, extend the local control of tu-mor, and improve a patient's quality of life.
