The imageology study of patients with the hippocampal sclerosis-associated medial temporal lobe epilep-sy
10.3936/j.issn.1002-0152.2014.09.001
- VernacularTitle:内侧颞叶癫痫患者海马硬化的影像学研究
- Author:
Wei YUE
;
Yajing ZHANG
;
Yalin GUAN
;
Lei XIANG
;
Shuling LIU
;
Yong JI
- Publication Type:Journal Article
- Keywords:
Hippocampal sclerosis;
Medial temporal lobe epilepsy;
MRI;
MRS
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(10):607-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the incidence and imageological features of patients with the hippocampal sclerosis-associated medial temporal lobe epilepsy. Methods Seventy-eight patients with the medial temporal lobe epi?lepsy were recruited from our hospital during February 2012 to December 2013. Magnetic resonance imaging (MRI) and resonance spectroscopy (MRS) analysis were conducted in patients with with the hippocampal sclerosis-associated medial temporal lobe epilepsy, patients with epilepsy without the medial temporal lobe diseases and healthy controls. Results The incidence of hippocampal sclerosis was 58.97%among patients with medial temporal lobe epilepsy which were significantly higher compared with either healthy control group or patients with epilepsy without the medial tempo?ral lobe diseases. The average hippocampal volume of the medial temporal lobe epilepsy group(2305.68±814.61 mm3、2456.71±743. 60 mm3)was significantly smaller compared with either healthy controls or patients with epilepsy without the medial temporal lobe diseases. MRI revealed increased T2WI signal and hippocampal atrophy in 74.55%of patients with hippocampal sclerosis-associated medial temporal lobe epilepsy. Sclerosis was detected on the left side (52.17%) and bilateral hippocampus (19.57%). MRS showed that NAA/(Cr ± Cho) significantly reduced (0.58± 0.19) in the hip?pocampal sclerosis. Conclusions Hippocampal sclerosis may be the main imaging features of the medial temporal lobe epilepsy which are characterized by the hippocampal atrophy and high T2WI signal.
