Influence of HLA typing on renal allograft function in patients receiving kidney from same donor
10.3969/j.issn.1673-4130.2015.05.001
- VernacularTitle:HLA 配型对接受同一供者肾的移植肾功能的影响
- Author:
Junjie WU
;
Baoxiang JIA
;
Dong ZHANG
;
Weiran MA
;
Xiuhong XU
- Publication Type:Journal Article
- Keywords:
renal transplant;
HLA mismatch;
renal function
- From:
International Journal of Laboratory Medicine
2015;(5):577-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of HLA mismatching on renal function in the kidney transplant patients re-ceiving pairs of allograft from the same donor.Methods 171 pairs of renal transplant patients receiving the kidneys from the same donors were investigated.They were admitted in our hospital before 2008.Their human leukocyte antigens (HLA)were typed with the commercial polymerase chain reaction (PCR)-sequence-specific primers (SSP)HLA typing kit (One Lambda,Inc.,USA;and GTI Diagnostics,USA).The serum creatinine (SCr)and blood urea nitrogen(BUN)were measured in the clinical laboratory of our hospital.Results Among 171 pairs of renal transplant patients,there were 162 recipients with HLA mismatch≤4,in which the re-nal function was remained stable in 107 recipients and lost or decreased in 55 patients.There were 180 recipients with HLA mis-match >4,in which the renal function was stayed normal in 84 recipients and lost or decreased in 96 patients.The difference in in-fluencing the renal function between the HLA mismatch≤4 and HLA mismatch>4 had statistical significance (χ2 =12.22,P <0.05).Conclusion Excellent HLA typing match has important significance for renal long term survival.
