Changes of cortisol and adrenocorticotrophic hormone levels in premature neonates with infectious diseases
10.3969/j.issn.1673-4130.2015.05.029
- VernacularTitle:感染性疾病早产儿皮质醇和促肾上腺皮质激素的变化
- Author:
Huaiwu ZHENG
;
Ling LIN
;
Biling ZHONG
;
Suqing QIU
;
Shengming WAN
- Publication Type:Journal Article
- Keywords:
infection;
premature infant;
adrenocortical insufficiency
- From:
International Journal of Laboratory Medicine
2015;(5):643-644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma cortisol and adrenocorticotrophic hormone(ACTH)levels in prema-ture neonates with the infectious diseases.Methods Ninety premature neonates in the neonatal department of our hospital were di-vided into the control group(30 cases),mild infection group(30 cases)and severe infection group(30 cases).The radioimmunoassay was adopted to detect the serum cortisol and ACTH levels on 1,3,7 d after birth in all subjects and the corresponding comparison was conducted.Results The cortisol levels on 1,3,7 d in the mild infection group were (193.04 ±39.48),(151.12 ±35.62 ), (128.37±27.47)ng/mL respectively,the level on 1 d was higher than that on 3,7 d (P <0.05),and the 3 d was higher than that on 7 d (P <0.05).The cortisol level on 1,3,7 d in the severe infection group were (99.43±50.17),(96.52 ±44.69),(131.13 ± 42.73)ng/mL respectively,and the level on 1,3 d was significantly lower than that on 7 d (P <0.05).Conclusion The relative ad-renocortical insufficiency exists in premature neonates with the early stage of severe infection and is manifested by the decline of plasma cortisol level,which could recover to the normal level on 7 d,but the plasma ACTH level has no relation with infection.
