Effect of Neoadjuvant Chemotherapy via Different Arteriovenous Ways on Ovarian Func-tion in Young Patients with Locally Advanced Cervical Cancer Post Surgery
10.3870/yydb.2015.03.017
- VernacularTitle:动静脉不同途径新辅助化疗对年轻局部晚期宫颈癌术后患者卵巢功能的影响
- Author:
Ying CHEN
;
Jing WANG
;
Saihua YANG
;
Ming TONG
- Publication Type:Journal Article
- Keywords:
Neoadjuvant chemotherapy;
Cancer,cervical,advanced/ locally;
Ovarian function
- From:
Herald of Medicine
2015;(3):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of neoadjuvant chemotherapy by different arteriovenous ways on ovarian function of patients with locally advanced cervical cancer after surgery. Methods We retrospectively studied 38 cases of young women (surgical age <45 years) who were diagnosed with locally advanced squamous cell carcinoma of the cervix and undergone radical hysterectomy with ovaries. According to the way of adjuvant chemotherapy, these cases were divided into 20 cases of group A (arterial embolization chemotherapy), 18 cases of group B (intravenous chemotherapy). Each patient underwent a course of chemotherapy. Then we retrospectively analyzed and compared serum estradiol (E2 ), follicle stimulating hormone (FSH), lute-inizing hormone (LH) in two groups before and after surgery to assess ovarian function. We compared E2 ,FSH and LH levels 2-3 weeks after chemotherapy (before surgery) and 1 month after surgery,and 6 months after surgery in two groups. Results The E2 levels in group A 1 month before and after surgery significantly decreased, while FSH increased compared with those be-fore chemotherapy(P<0. 05). LH levels in two groups at different time points and 6 months after surgery showed no significant difference (P>0. 05) compared with those before chemotherapy. the E2 , FSH and LH levels in group B at different time points presented no significant difference (P>0. 05). Only E2 level in group A was significantly lower than that in group B before surger-y. Conclusion For patients with locally advanced cervical cancer, the effect of arterial embolization chemotherapy before sur-gical intervention on ovarian function is transient and reversible, while intravenous chemotherapy before surgery exerts few effects on ovarian function. Retaining ovaries in radical hysterectomy is a safe and effective method to protect the endocrine function for young patients with locally advanced cervical cancer.
