18F-FLT and 18F-FDG PET/CT Scan in Diagnosing Lung Cancer:A Meta-analysis
10.3969/j.issn.1005-5185.2015.01.015
- VernacularTitle:18F-FLT与18F-FDG PET/CT诊断肺癌的Meta分析
- Author:
Longlong WANG
;
Jingjian WANG
;
Bing HAN
;
Yanzhong GAO
;
Qing ZHAO
;
Minjuan WU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Positron-emission tomography;
Tomography,X-ray computed;
Fluorodeoxyglucose F18;
Thymine nucleotides;
Contrast media;
Meta-analysis
- From:
Chinese Journal of Medical Imaging
2015;(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To assess the diagnostic value of 18F-FLT and 18F-FDG PET/CT scan in patients with lung cancer. Materials and Methods Computer-based retrieval was performed on Medline, PubMed, EMbase, Wanfang data, CNKI and the Cochrane Library to search reports on diagnostic value of lung cancer with 18F-FLT and 18F-FDG PET/CT scan. The quality of included studies was evaluated according to quality assessment of diagnostic accuracy studies (QUADAS), and MetaDisc software was adopted to conduct meta-analysis. The pooled specificity, sensitivity, and diagnostic odds ratio (DOR) were calculated. The heterogeneity was tested. The summary receiving operating characteristic (SROC) curve was drawn, and the areas under the curve (AUC) as well as Q* were measured. Results Ten studies were included. Meta-analysis showed pooled sensitivity was 0.88, pooled specificity was 0.56, DOR was 9.10, AUC was 0.8102, Q*was 0.7448 for FDG group;pooled sensitivity was 0.79, pooled specificity was 0.78, DOR was 12.50, AUC was 0.8440, Q*was 0.7756 for FLT group. Conclusion Both 18F-FDG and 18F-FLT have well diagnostic value for lung cancer, but the specificity of 18F-FLT is higher than that of 18F-FDG in the diagnosis of lung cancer.
