Value of serum APOM concentration for diagnosis of bacterial pneumonia and judgment of disease severity
10.3969/j.issn.1673-4130.2015.05.006
- VernacularTitle:载脂蛋白M对细菌性肺炎的诊断和病情严重程度的判断价值
- Author:
Tingting ZHAO
- Publication Type:Journal Article
- Keywords:
apolipoprotein M;
bacterial pneumonia;
ROC curve
- From:
International Journal of Laboratory Medicine
2015;(5):588-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum apolipoprotein M (APOM)concentration in the diagnosis of bacterial pneumonia and its disease severity evaluation.Methods The serum APOM concentration was examined in 250 cases of pneumonia and 50 healthy controls by using the double antibody sandwich ELISA.The ROC curve was used to evaluate the diagnostic value of APOM on bacterial pneumonia and the Bayes discriminant analysis was adopted to construct the discriminant equation based on APOM concentration for evaluating its discriminant significance to the disease severity.Results The serum APOM concentration in the bacterial pneumonia group was (28.9±10.5)μg/mL,which was significantly higher than (19.4±8.93)μg/mL in viral pneu-monia group,(16.4±5.62)μg/mL in the other pneumonia group and(18.1 ±6.15)μg/mL in the healthy controls,the differences had statistical significance(P <0.01).The area under ROC curve for APOM in diagnosing bacterial pneumonia could reach 0.843, showing the good sensitivity and specificity.Moreover,the serum APOM concentration was positively correlated with the disease severity of bacterial pneumonia.The discriminant equation based on APOM concentration as well as sex,age,systolic pressure,body temperature and heart rate could better conduct the classification on the disease severity of bacterial pneumonia and its accuracy could reach to 86.7%.Conclusion The serum APOM concentration has an important clinical value for the diagnosis of bacterial pneumonia and its disease severity evaluation.
