Several proteins involved in absorption of cholesterol in small intestine
10.7644/j.issn.1674-9960.2015.06.015
- VernacularTitle:小肠胆固醇吸收相关蛋白的研究进展
- Author:
Min YUAN
;
Donggang XU
- Publication Type:Journal Article
- Keywords:
intestine,small;
cholesterol;
intestinal absorption;
NPC1L1;
ABCG5/ABCG8;
ACAT2;
LXR
- From:
Military Medical Sciences
2015;(6):472-475
- CountryChina
- Language:Chinese
-
Abstract:
Several proteins are involved in the absorption of cholesterol in small intestine.Niemann-Pick C1 like 1 (NPC1L1) mainly mediates the absorption of cholesterol, and acyl-coenzyme A ( CoA)∶cholesterol acyltransferase 2 (ACAT2) catalyzes the free cholesterol absorpted by intestine into cholesterol ester,while unesterified free cholesterol is secreted into intestinal lumen by ATP-binding cassette(ABC) transporters G5/G8(ABCG5/ABCG8).Transcription factor liver X receptor( LXR) plays an important role in the process of intestinal cholesterol absorption.The research progress in NPC1L1,ABCG5/ABCG8,ACAT2 and LXR is reviewed in this article.
