Research progress on relationship between histone code and glio-blastoma
10.3969/j.issn.1000-8179.20142143
- VernacularTitle:组蛋白密码与胶质母细胞瘤关系的研究进展
- Author:
Hongjun SUN
;
Zhiyun LI
- Publication Type:Journal Article
- Keywords:
glioblastoma;
histone code;
histone modification;
Epigenetics
- From:
Chinese Journal of Clinical Oncology
2015;(5):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Histone codes are characterized by the type, location, and modification of amino acids in proteins. Recent research has shown that histone codes are closely related to glioblastoma (GBM). In GBM cells, the combined effects of various effector proteins and histone-modified target sites control the state of chromatins, which further affects the epigenetic phenomena, including GBM cell DNA replication and gene expression and regulation. GBM histone code information exists in histone acetylation, methylation, phos-phorylation, ubiquitination, and other post-translational modification processes. Briefly, this study on the relationship between histone code and GBM provides further molecular targets to develop the clinical diagnosis and treatment of GBM.
