Comparison of Transdermal Penetration of Two New Kinds of Triamcinolone Acetonide Lipid Carriers
10.3870/yydb.2015.03.022
- VernacularTitle:两种曲安奈德新型脂质载体经皮渗透性比较
- Author:
Guoqiang WANG
;
Zhaofeng LIANG
;
Junfeng BAN
;
Guanghan DENG
;
Jiacheng LIN
;
Zhufen LYU
- Publication Type:Journal Article
- Keywords:
Triamcinolone acetonide;
Lipoparticles;
Ethosomes;
Percutaneous penetration
- From:
Herald of Medicine
2015;(3):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare transdermal penetration of triamcinolone acetonide liposparticles (TAA-LPPs) and TAA-Ethosomes in vitro. Methods The TAA-LPPs and TAA-Ethosomes were produced and the morphology was observed by transmission electron microscope,particle size was detected by laser particle analyzer. The percutaneous permeability in vitro was tested by modified Franz diffusion pools. The amount of penetrated triamcinolone acetonide and the retention in the skin were de-termined by HPLC. Results The shape of TAA-LPPs and TAA-Ethosomes was almost spherical with mean diameter of (99. 9±1. 3) and (105±1. 4) nm, respectively. The cumulative transdermal penetration of TAA-LPPs, TAA-Ethosomess and TAA suspension was (53. 59±4. 40),(87. 03±4. 87),and (30. 54±8. 61) μg·(cm2 ) -1 , respectively . The drug retention in the skin after 32 h was (1. 02±0. 13), (0. 62±0. 08), (0. 55±0. 17) μg·(cm2 ) -1 , respectively. Conclusion TAA-LPPs is better for transdermal administration of triamcinolone acetonide by reducing systemic absorption of the drug.
