Regulation of ICC Autophagy -- New Target for Treatment of Intestinal Dysmotility in Ulcerative Colitis
10.3969/j.issn.1008-7125.2015.06.010
- VernacularTitle:ICC 自噬调控--溃疡性结肠炎肠动力紊乱治疗的新靶点
- Author:
Yancheng DAI
;
Yali ZHANG
;
Zhipeng TANG
- Publication Type:Journal Article
- Keywords:
Colitis,Ulcerative;
Gastrointestinal Motility;
Interstitial Cells of Cajal;
Autophagy
- From:
Chinese Journal of Gastroenterology
2015;(6):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal dysmotility symptoms,such as abdominal pain,diarrhea and tenesmus are frequently seen in patients with ulcerative colitis( UC). Interstitial cells of Cajal( ICC)has been accepted as a therapeutic target for gastrointestinal motility disorders and regulation of autophagy might be a potential strategy for various diseases. Study on relationship between intestinal dysmotility in UC and ICC autophagy and the intervention mechanism of related drugs will benefit the controlling of disease activity,relieving of dysmotility symptoms and improving of quality of life in UC patients. In this review article,the possible relationship between intestinal dysmotility in UC and ICC autophagy,as well as the possibility of regulating ICC autophagy as a treatment strategy for UC intestinal dysmotility were summarized.
