Effect of atorvastatin on the prognosis of cerebral infarction and the changes of serum CRP

VernacularTitle:不同剂量阿托伐他汀治疗脑梗死疗效观察
Author: Huijun WANG
Publication Type:Journal Article
Keywords: Brain infarction; Atorvastatin; C-reactive protein; Dose-Response Relationship,drug
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(5):648-649
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of atorvastatin on the prognosis of cerebral infarction and the changes of serum CRP.Methods 131 cases of patients were divided into the high dose (40mg) group of 69 cases and small dose(10mg) group of 62 cases according to the use of drug doses .The efficiency and changes of CRP in two groups after 4 weeks of treatment was observed .Results Comparison of therapeutic results in patients after treat-ment,the total effective rate of the high dose group was 89.6%,the low dose group was 75.8%,the total efficiency of the two groups had significant difference (χ2 =4.61,P<0.05);CRP of the two groups after treatment had significant difference(t=16.82,7.10,all P<0.05) with before treatment;CRP of the high dose group had significant difference with the low dose group(t=9.64,P<0.05).Conclusion High dose atorvastatin can significantly improve the prog-nosis of patients ,and can obviously reduce the CRP level ,which is worthy of clinical application .