Curative effects of valsartan combined with Bailing capsule for the treatment of diabetic nephropathy
10.3760/cma.j.issn.1008-6706.2015.06.030
- VernacularTitle:缬沙坦联合百令胶囊治疗早期糖尿病肾病疗效分析
- Author:
Li DIAO
;
Kebin GAO
- Publication Type:Journal Article
- Keywords:
Valsartan;
Bailing capsule;
Diabetic nephropathy;
Curative effects
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(6):886-888
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the curative effects and clinical safety of using valsartan combined with Bailing capsule to treat diabetic nephropathy ( DN) .Methods In our hospital ,90 patients with diabetic nephropathy were chosen and divided into the two groups ( 45 cases in each group ):the control group treated with 80mg/d of valsartan and the observation group given bailing capsules 9g/d on basis of the control group .Before and after 16 weeks treatment,two groups′24h urine trace albumin excretion rate (UAER),potassium,serum creatinine (SCr), urea nitrogen ( BUN) ,total cholesterol ( TC) ,triglycerides ( TG) ,fasting plasma glucose ( FPG) and blood rheology changes were recorded and compared .Results After treatment the observation group′s high shear viscosity ,low shear viscosity,whole blood reductive viscosity and blood plasma viscosity all significantly decreased ( t=6.236,10.659, 12.509 and 7.269,all P<0.05),and these indexes were significantly lower than those of the control group ( t=6.365,6.054,9.057 and 6.431,all P<0.05);Compared with before treatment 24h urine trace albumin excretion rate (UAER),potassium,serum creatinine (SCr),urea nitrogen (BUN),total cholesterol (TC),triglycerides (TG) and fasting plasma glucose ( FPG) of the two groups all decreased significantly ( t≥2.081,all P<0.05);After treat-ment,the observation groups′24h UAER,SCr,BUN,TC,TG and BUN all significantly decreased more than those of the control group (t≥2.211,all P<0.05);After treatment potassium,FPG,SBP and DBP of the two groups all had no significant difference (t≤1.976,all P>0.05);No adverse reactions such as heart ,liver and kidney happened in the two groups .Conclusion Using valsartan in joint with Bailing capsule for the treatment of diabetic nephropathy ( DN) has distinct curative effects and no obvious adverse reactions ,which is worthy of clinical promotion .
