Microenvironment and the occurrence and development of cancer stem cells
10.3760/cma.j.issn.1673-422X.2015.02.012
- VernacularTitle:微环境与肿瘤干细胞的发生和发展
- Author:
Xiaoying ZHANG
;
Xiaofang WANG
- Publication Type:Journal Article
- Keywords:
Neoplastic stem cells;
Neovascularization,pathologic;
Cell hypoxia;
Tumor microenvironment
- From:
Journal of International Oncology
2015;42(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of tumor depends not only on the tumor itself,but also depends on the soil survival of tumor cells,that is the tumor microenvironment.Studies confirm that the changes of blood vessels and hypoxic of tumor microenvironment maintain the stemness of cancer stem cell,and further strengthen the ability of tumor invasion and metastasis.Studying the molecular mechanism of tumor development from angiogenesis and lack of oxygen can provide new ideas for the clinical targeted therapy.
