A new coumarin and eight known polyphenolics from Radix Campylotropidis Hirtellae

VernacularTitle:大红袍中一个新的香豆素和八个已知酚酸类化合物
Author: Yuliang ZENG ; Yanhua XIAO ; Ying TIAN ; Junxing DONG
Publication Type:Journal Article
Keywords: Campylotropis hirtella(Franch.) Schindl; hedysarimcoumestan; chemical constituents
From: Military Medical Sciences 2015;(7):528-531
CountryChina
Language:Chinese
Abstract: Objective To investigate the chemical constituents of the Radix Campylotropidis Hirtellae ( RCH ) . Methods 60%ethanol extract of the RCH was separated by column chromatography on silica gel, ODS and Sephadex LH-20 to obtain aimed compounds.Structures of the compounds were investigated by modern spectroscopy.Results Nine compounds were separated from Campylotropis hirtella ( Franch.) Schindl, and the structure of the new compound 1 was determined by spectral analysis and named hedysarimcoumestanⅠ( 1 ) , while the others were identified as the known isotrifoliol(2), hedysarimcoumestan B(3), umbelliferone(4), orobol(5), quercetin(6),(+) catechin(7), kaempferol (8) and dihydrokaempferol(9) .Conclusion Compound 1 is a new compound and 3-5 are separated from C.hirtella for the first time.The screening results of inhibition of H5N1 virus activity show that compound 5 has some inhibitory activity at a level of 50.0 μg /ml.