Research progress in antidotes of nerve agents in the USA
10.7644/j.issn.1674-9960.2015.07.018
- VernacularTitle:美国神经性毒剂救治研究进展
- Author:
Jin CHENG
;
Guorong DAN
;
Yuanpeng ZHAO
;
Jian WANG
;
Feng YE
;
Jiqing ZHAO
;
Zhongmin ZOU
- Publication Type:Journal Article
- Keywords:
nerve agent;
organophosphorus compounds;
drug development;
acetylcholinesterase;
butyrylcholinesterase;
cholinesterase inhibitors;
neuroprotective agent
- From:Military Medical Sciences
2015;(7):565-568
- CountryChina
- Language:Chinese
-
Abstract:
Nerve agent not only inhibit acetylcholinesterase ( AChE) at an early stage, but also induce prolonged and progressive neuroinflammation and delayed neurodegeneration.Recently, the US National Institute of Health ( NIH) has sponsored some major programs of toxic mechanisms and treatment of nerve agents, which aims at the development of quick and effective treatment to acute intoxication and delayed effect.The experimentally effective new antidotes mainly include AChE-targeting drugs, broad-spectrum reactivators and scavengers, antiinflamatory and nerve protection drugs.
