Advances in research on enterovirus 71 vaccines
10.7644/j.issn.1674-9960.2015.07.015
- VernacularTitle:肠道病毒71型疫苗研究进展
- Author:
Jie MA
;
Yongqiang DENG
;
Chengfeng QIN
;
Ede QIN
- Publication Type:Journal Article
- Keywords:
enterovirus 71;
inactivated vaccine;
attenuated live vaccine;
subunit vaccine;
clinical trial
- From:
Military Medical Sciences
2015;(7):553-556
- CountryChina
- Language:Chinese
-
Abstract:
Enterovirus 71 (EV71) is one of the primary causative agents of hand, foot and mouth disease in children and closely associated with severe neurological complications and even deaths.EV71 outbreaks have occurred throughout the Asia-Pacific region since 1990s, posing global public health threat;however, no specific therapeutic strategy exists for severe EV71 infection.Several inactivated vaccine products have entered or finished the clinical trial stage, and some novel vaccine candidates, including live attenuated, subunit, and virus-like particle, show great potential for further develop-ment.This review summarizes the present situation and progress in the development of EV71 vaccines.
