Topiramate monotherapy for alcohol dependence:a meta-analysis
10.3936/j.issn.1002-0152.2015.06.006
- VernacularTitle:托吡酯单药治疗酒依赖的meta分析
- Author:
Qiaozhi HU
;
Mei ZHAN
;
Ling WANG
;
Ting XU
- Publication Type:Journal Article
- Keywords:
Topiramate;
Alcohol dependence;
Systematic review;
Meta-analyses
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(6):349-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of topiramate monotherapy in the treatment of alcohol de?pendence. Methods The Cochrane library, PunMed, EMBase, CNKI, VIP and CBM database were searched to collect the randomized contolled trials (RCTs) of topiramate monotherapy to compare with placebo or positive control drug in al?cohol dependence. Data were extracted from the included literatures after the literatures’qualities were assessed. The meta-analyses were conducted with RevMan 5.2 software. Results Thirteen trials were included. Compared with place?bo, topiramate reduced score of obsessive compulsive drinking scale(MD=-5.90,95%CI:-10.99~-0.82,P=0.02), de?creased drinks per drinking day(MD=-6.94,95%CI:-12.20~-1.68,P=0.01), and increased percentage of days absti?nent(MD=15.36,95%CI:4.15~6.56,P<0.01). The incidence of paraesthesia, taste perversion, weight loss, memory or concentration impairment, dizziness, psychomotor retardation in topiramate group was higher. But the incidence of other adverse events was similar between groups. Compared with naltrexone, topiramate significantly postponed the days to first relapse(MD=2.10,95%CI:0.23~3.97,P=0.03). The adverse events were similar between groups. Conclusions Topira?mate in treatment of alcohol dependence is effective and safety.
