The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms
10.3969/j.issn.1007-3969.2015.02.006
- VernacularTitle:胰腺神经内分泌肿瘤中DJ-1蛋白高表达的临床意义
- Author:
Lixin YANG
;
Lina ZHANG
;
Tianbiao ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neuroendocrine neoplasms;
DJ-1;
Immunohistochemistry;
Survival analysis
- From:
China Oncology
2015;(2):112-118
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The symptoms of pancreatic neuroendocrine neoplasms (PNENs) are complicated, that might lead to misdiagnosis. This study aimed to detect the expression level of DJ-1 in PNENs and explore the clinical significance of DJ-1 in PNENs.Methods:DJ-1 protien levels in the serum of 16 cases of PNENs patients and 25 cases of healthy persons were detected by ELISA analysis; The expressions of DJ-1 in 78 cases of PNENs tissues were detected by immunohistochemical staining.Results:The DJ-1 level in the serum of PNENs patients was signiifcantly higher than healthy persons (36.19±6.71vs 24.68±5.94 ng/mL;P<0.001);53.8% (42/78) cases of PNENs tissues showed DJ-1 positive staining; DJ-1 expression level in PNENs tissues had signiifcantly positive correlation with lymph node metastasis (P=0.033), distant metastasis (P=0.017), TNM stage (P=0.012), and pathology grade (P=0.049); As a dependent risk factor, DJ-1 expression was signiifcantly associated with shorter OS (P=0.003) and DFS (P=0.018) of PNENs patients.Conclusion:High expression of DJ-1 protein correlated with invasion and metastasis, disease progression, and poor prognosis in PNEN.
