P53 and MDM2 overexpression in oral cancer in Vietnamese
- Author:
Nguyen Thi Hong
- Publication Type:Journal Article
- Keywords:
oral cancer, protein overexpression
- MeSH:
Mouth Neoplasms;
diagnosis;
Genes, p53;
Proto-Oncogene Proteins c-mdm2
- From:Journal Ho Chi Minh Medical
2004;8(4):212-215
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The previous study detected 15/18 cases of oral squamous cell carcinoma expressing p53 positive immunostaining: 7/8 cases with p53 mutation and 8/10 cases without p53 mutation. In this study, immunohistochemical staining showed mdm2 overexpresion in 7/18 cases, combined p53/mdm2 overexpression in 6/18 cases, mdm2 overexpression in 5/8 p53-positive without mutation cases. These results indicated that p53 overexpression can be associated with p53 gene mutation, as well as mdm2 overexpression in the oral carcinogenensis
