Fastigial cerebellar nucleus may be involved in the pathogenesis of post-stroke depression through the cerebellum-hypothalamic pathways in rats Fastigial cerebellar nucleus may be involved in the pathogenesis of post-stroke depression through the cerebellum-hypothalamic pathways in rats
10.7652/jdyxb201502004
- VernacularTitle:小脑顶核通过小脑-下丘脑通路参与卒中后抑郁的实验观察小脑顶核通过小脑-下丘脑通路参与卒中后抑郁的实验观察
- Author:
Yuan LI
;
Rubo SUI
;
Xin ZHANG
;
Yuhan LIN
- Publication Type:Journal Article
- Keywords:
medial cerebellar nucleus;
lateral hypothalamic area;
cerebellum-hypothalamic pathway;
patho-genesis;
post-stroke depression
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(2):164-168
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To investigate whether medial cerebellar nucleus may be involved in the pathogenesis of post-stroke depression (PSD)and explore the pathway that mediates this effect.Methods Healthy SD rats were randomly divided into five groups:control group,stroke group,PSD group,medial cerebellar nucleus (Med)lesion group,and superior cerebellar peduncle (xscp)lesion group.The ethological score of depression was evaluated.The neurotransmitters of Glu and GABA in the lateral hypothalamic area were detected by high performance liquid chromatography.Results Compared with those in control group,the levels of GABA and Glu expressions did not significantly differ in the lateral hypothalamic area in stroke group (P > 0.05 ).In contrast,the levels in PSD group,Med lesion group and xscp lesion group were lower than those in stroke group to different extent (P <0.01). Conclusion These results preliminarily show that medial cerebellar nucleus may participate in the pathogenesis of post-stroke depression,which may be mediated by the cerebellum-hypothalamic pathway.
