Expressions of C-Met and HGF in tongue squamous cell carcinoma and their clinical significance
10.7652/jdyxb201502020
- VernacularTitle:C-Met 蛋白与 HGF 蛋白在舌鳞癌细胞中的表达及临床意义
- Author:
Jie Lü
;
Debao ZHANG
;
Jian CHEN
;
Jun HU
- Publication Type:Journal Article
- Keywords:
tongue squamous carcinoma;
C-Met;
hepatocyte growth factor (HGF);
lymph node metastasis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(2):245-248
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To study the expressions of C-Met and hepatocyte growth factor (HGF)in tongue squamous cell carcinoma and their clinical significance.Methods We analyzed 46 patients (the treatment group) with tongue squamous carcinoma and 27 patients (the control group)with benign tumor treated in our hospital between June 201 1 and May 2013.The expressions of C-Met and HGF were detected by immunohistochemistry. Results In the experimental group,C-Met negative expression rate was 21.7% (10/46),weak positive expression rate was 26.1% (12/46),and strong positive expression rate was 52.2% (24/46).The above expression rates were 77.8% (21/27),1 5.8% (5/27),and 3.7% (1/27)in the control group.The two groups differed significantly (P <0.001).In the experiment group,the negative expression of HGF protein was 1 7.4% (8/46 ),weak positive expression rate was 58.7% (27/46),and strong positive expression rate was 23.9% (1 1/46).The above expression rates in the control group was 63.0% (1 7/27 ),37.0% (10/27 ),and 0.0% (0/27 ).The two groups differed significantly (P <0.001).The expression of C-Met protein was significantly related to lymph node metastasis (P <0.05).The expression of HGF protein was significantly related to pathological grading and lymph node metastasis (P <0.05).Conclusion The expressions of C-Met and HGF in tongue squamous cell carcinoma are significantly higher.And the occurrence and development of tongue squamous cell carcinoma are closely related to the expressions of C-Met and HGF.
