The role of arginase in the airway inflammation and airway remodeling
- VernacularTitle:精氨酸酶在气道炎症和气道重塑中的作用
- Author:
Wei DAI
;
Jie WU
;
Xiaofeng XIN
- Publication Type:Journal Article
- Keywords:
Arginase;
Asthma;
Nitric oxide;
Arginine
- From:
Journal of Medical Postgraduates
2015;(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is the chronic airway inflammatory disease that characterized by reversible airflow limitation .The presence of airway inflammation could lead to airway remodeling .In recent years , many studies have found that arginase plays an im-portant role in the airway inflammation and airway remodeling of asthma .It not only reduces airway release nitric oxide and increases airway hyperresponsiveness , but also its metabolites such as putrescine , proline, etc can induce cell proliferation and collagen synthe-sis, leading to airway remodeling .In this paper , the arginase and its role in the pathogenesis of asthma are discussed .
