Relationship between PCSK9 gene polymorphorism rs11206510 with blood lipid level and coronary heart disease
10.11958/j.issn.0253-9896.2015.02.017
- VernacularTitle:PCSK9基因rs11206510多态性与血脂及冠心病的关系
- Author:
Yanping TAN
;
Yin LIU
;
Jing GAO
;
Genyi SUN
- Publication Type:Journal Article
- Keywords:
coronary disease;
polymorphism,genetic;
apolipoproteins;
lipoproteins;
PCSK9
- From:
Tianjin Medical Journal
2015;(2):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between PCSK9 gene polymorphism with lipid metabolism and CHD risk among population within Tianjin, China. Methods Patients from Tianjin Chest Hospital were selected (n=778) and divided into coronary heart disease (CHD) group (n=502) and control group (n=276). Immediately after admission, tri?glyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A (ApoA 1) and apolipo?protein B (ApoB) were tested and genotype TT,TC and CC were determined. Results In CHD group, LDL-C level is higher in TC genotype individuals than that in TT genotype individuals with statistical significance (P<0.05). CHD group and the control group were dominated by TT genotype with no statistical difference between their allele frequency distribution nor genotype frequency distribution(P>0.05). The total population allele frequencies were T 96.1%(1 495/1 556), C 3.9%(61/1 556);genotype frequencies were TT 92.2%(717/778), TC 7.8%(61/778). Multivariate Logistic regression analysis revealed that ApoA1 and HDL-C were inversely associated with coronary heart disease, therefore are protective factors for coronary heart disease. Conclusion The study found that TC genotype is correlated with serum LDL-C increase in group CHD, and the incidence of allele C showed no obvious connection with CHD.
