The expressions of HSFl and XAF1 in endometrial carcinoma and their correlation analysis
10.7652/jdyxb201502017
- VernacularTitle:HSF1与 XAF1基因在子宫内膜癌组织中的表达及其相关性分析
- Author:
Zhuo ZHOU
;
Jia LI
;
Qianfeng ZHANG
;
Jianfang ZHANG
;
Jian WANG
;
Biliang CHEN
- Publication Type:Journal Article
- Keywords:
endometrial carcinoma;
heat shock transcription factor 1 (HSF1 );
XIAP-associated factor 1 (HSF1);
cell apoptosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2015;(2):231-234
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To test the expressions of heat shock transcription factor 1 (HSF1 )and XIAP-associated factor 1 (XAF1 )in different endometrial tissues,and analyze the association between their expressions and the clinicopathological features of this malignancy.Methods The expressions of HSF1 and XAF1 in 64 cases of endometria1 carcinoma (EC group)and 33 cases of normal endometrial tissues (NE group)were detected with immunohistochemistry S-P method.The correlation was observed.Results The positive expression rate of HSF1 was much higher in EC group than in NE group (76.6% vs .36.4%,P <0.05).The positive rate of XAF1 was 31.2% in EC group and 72.7% in NE group (P <0.05).The positive expressions of HSF1 and different subgroups of histological grade,myometrial invasion and lymph node metastasis were significantly different (P <0.05)in EC group.The positive expressions of XAF1 and different subgroups of histological grade,myometrial invasion,clinical stage and lymph node metastasis were significantly different (P < 0.05 )in EC group.There was a negative correlation between HSF1 and XAF1 in EC group (P <0.05).Conclusion In EC group,the high expression of HSF1 may inhibit the growth of XAF1 expression,cause excessive growth of cancer cells,reduce the apoptosis of cancer cells,and finally lead to the further development of tumors.
