New therapies for obstructive sleep apnea-hypopnea syndrome
- VernacularTitle:治疗阻塞性睡眠呼吸暂停的新疗法介绍
- Author:
Xiaoyan FU
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea;
Therapy;
Hypoglossal nerve;
Nasal device;
Clinical trials
- From:
Journal of Medical Postgraduates
2015;(2):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Obstructive sleep apnea-hypopnea syndrome ( OSAHS) is a prevalent disorder often associated with multisystem dys-function.Available therapies are limited by either lack of long-term adherence or low response rates .Two emerging therapies hold promise in providing alternatives to patients with OSA .The first stems from the importance of the upperairway dilator muscles in main-taining pharyngeal stability .Electrical stimulation of the genioglossus muscle improves both upper-airway diameter and ameliorates pha-ryngeal obstruction .The results of phase ⅠandⅡclinical trials hold promise , but the reported improvements in the apnea-hypopnea index vary between subjects and long-term safety needs further studies .The second technology relies on creating an increased expiratory nasal resistance via a bidirectional valve designed to be worn just inside the nostrils .Initial findings of clinical trials suggest reduction in severity of sleep apnea and subjective daytime sleepiness .Considerable heterogeneity in response to the nasal device was noted de-spite the high adherence rates .It remains unclear which patients will likely benefit from these devices .
