Dissolution Determination Method for Nisoldipine Tablets
- VernacularTitle:尼索地平片溶出度测定方法
- Author:
Zhang HAO
- Publication Type:Journal Article
- Keywords:
Nisoldipine tablets;
Dissolution;
Ultraviolet spectrophotometry
- From:
China Pharmacist
2015;(2):350-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a dissolution determination method for nisoldipine tablets. Methods: The detection was car-ried out according to the second method described in ChP VolumeⅡappendix XC. The medium was 600 ml hydrochloric acid solution (0. 1 mol·L-1 ) containing 0. 05% SDS, the rotation speed was 75 r·min-1 , and the UV detection wavelength was at 238nm. Re-sults:The linear range of nisoldipine was 4-14 μg·ml-1(r=0. 999 9),and the average recovery was 100. 5%(RSD=1. 1%, n=9). Conclusion:The method is simple, accurate and reliable, and can be used in the dissolution determination of nisoldipine tablets.
