Relationship of TSH with atherosclerosis-related factors in subclinical hypothyroidism
10.3760/cma.j.issn.1000-6699.2015.02.009
- VernacularTitle:亚临床甲状腺功能减退症患者 TSH 与动脉粥样硬化相关因子关系的研究
- Author:
Limin TIAN
;
Bin YANG
;
Cuixia GAO
;
Jing LIU
;
Qian GUO
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Thyroid-stimulating hormone;
Atherosclerosis;
L-thyroxine
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
Two hundred and fifty patients with subclinical hypothyroidism ( SCH) and 120 euthyroid volunteers were recruited for the study, SCH patients were stratified into 2 groups according to TSH levels(group A:TSH<10 mIU/ L; group B: TSH>10 mIU/ L). All subjects were examined for clinical characteristics, thyroid profile, lipid profile, and biomarkers of early atherosclerosis. Patients in group B received L-thyroxine replacement treatment to achieve euthyroidism. After 6 months of stable euthyroidism all measurements were repeated. SCH patients had higher levels of total cholesterol(TC), low-density lipoprotein-cholesterol(LDL-C), asymmetric dimethyl arginine (ADMA), carotid artery intima media thickness(CIMT), thromboxane B2(TXB2), and C-reactive protein(CRP) but with lower nitric oxide(NO) level compared with euthyroid subjects. Levels of TC, LDL-C, CIMT, TXB2, and ADMA decreased, and NO level increased significantly after 6 months of euthyroidism. TSH was positively correlated with TC, LDL-C, CIMT, ADMA, and TXB2; and negatively correlated with NO. Based on multivariate regression analysis, TSH was an independent influential factor of CIMT and NO. We conclude that raised TSH is an important risk factor of atherosclerosis in SCH.
