Diagnosis and treatment of 6 cases with Paget′s disease of bone
10.3760/cma.j.issn.1000-6699.2015.02.011
- VernacularTitle:畸形性骨炎六例的临床诊治分析
- Author:
Yan ZHENG
;
Hongquan DU
;
Zhenlin ZHANG
- Publication Type:Journal Article
- Keywords:
Osteitis deformans;
Paget′s disease of bone;
Diagnosis;
Bisphosphonates;
Treatment
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Six cases of Paget′s disease of bone, including 5 males and 1 female, aged (57. 7 ±11. 8) years old, were recruited. Mean duration of disease was (7. 5±6. 5) years. Clinical manifestations were bone pain and bone deformity. The lesions mainly reside in the pelvis and femur. X-ray film showed typical lesion of Paget′s disease of bone, such as impaired bone trabecular structure with coarseness and disorder, cortical thickening, medullary cavity narrowing and skeletal deformation. Bone scan revealed abnormal radionuclide concentration in the involved bone. Serum alkaline phosphatase ( ALP) in 6 patients was increased ( median 235 U/ L). 5 patients received zoledronic acid sodium intravenous infusion therapy. Bone pain was relieved obviously in 5 patients after treatment for 2-3 months. Physical activity was greatly improved, and serum ALP levels significantly decreased.
