Potential role of NF-κB signaling pathway in osteoporosis with by iron accumulation

VernacularTitle:NF-κB通路在骨质疏松伴铁蓄积中的潜在作用
Author: Xiao WANG ; Hua LIN ; Youjia XU
Publication Type:Journal Article
Keywords: NF-κB; Iron metabolism; Osteoclasts; Osteoporosis
From: Chinese Journal of Endocrinology and Metabolism 2015;(2):192-194
CountryChina
Language:Chinese
Abstract: [Summary] Osteoporosis in elderly women are commonly accompanied by elevated levels of ferritin. Abnormal iron metabolism plays a key role in the progress of osteoporosis. Research on bone metabolic disorders caused by iron accumulation remains at the exploratory stage, including NF-κB pathway in differentiation of osteoclasts. A review on the relationship between NF-κB pathway and osteoporosis induced by iron accumulation is herewith presented, with a view to provide further ideas for transforming the clinical outcomes.