Synthesis of 10-Position Schiff Base Derivatives of Emodin and Preliminary Investigation of Anti-tumor Ac-tivity in vitro
- VernacularTitle:大黄素10位希夫氏碱衍生物的合成与体外抗肿瘤活性初步研究
- Author:
Xiumei ZHANG
;
Gang ZHENG
;
Jinjun WANG
- Publication Type:Journal Article
- Keywords:
Emodin;
Schiff base;
Derivatives;
Anti-tumor activity
- From:
China Pharmacist
2015;(2):194-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To synthesize 10-position schiff base derivatives of emodin and study the anti-tumor activity. Methods:The 10-position schiff base derivatives of emodin were synthesized through emodin reacting with ammonia derivatives in absolute alcohol with acetic acid as the catalytic agent. Their structures were characterized by 1 H-NMR and ESI-MS, and the anti-tumor activity on k562 cells was determined by MTT method. Results:Three 10-position schiff base derivatives were synthesized and the structures were confirmed, and the IC50 on k562 cells was 4. 5, 3. 8 and 2. 0 μmol·L-1 , respectively. Conclusion:The 10-position schiff base de-rivatives of emodin can improve the anti-tumor activity and druggability of the parent compound, which are worthy of further study.
