Effect of 5 Chinese Herbal Medicinal Ingredients on the Activity of Carboxylesterase 1 and 2 in vitro
- VernacularTitle:5种中药成分体外对羧酸酯酶活性的影响研究
- Author:
Xiping LI
;
Yanjiao XU
;
Chengliang ZHANG
;
Daochun XIANG
;
Chengyang FENG
;
Dong LIU
- Publication Type:Journal Article
- Keywords:
Chinese medicine monomer;
Carboxylesterases;
Imidapril;
Irinotecan
- From:
China Pharmacist
2015;(2):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the inhibitory effect of 5 Chinese herbal medicinal ingredients baicalin, andrographolide, hes-peridin, polyphenols and daidzein on the activity of carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2). Methods: The spe-cial probes respectively for CES1 and CES2, namely imidapril and CPT-11, imidaprilat and SN-38, were used to investigate the poten-tial effect of the above drugs on CES1 and CES2 in rat liver microsomes incubation system. Results:Compared with that in the control group, the activity of CES1 and CES2 was not significantly influenced by the above 5 Chinese herbal medicinal ingredients ( P <0. 05). Conclusion:Baicalin, andrographolide, hesperidin, polyphenols and daidzein exhibit no inhibitory effect against CES1 and CES2, and further studies should be conducted to confirm the effect in vivo.
